Mes données de santé
The information site for patients treated within the Unicancer network or included in Unicancer network clinical trials. 

About us

Objectives

Constitutional polymorphisms and response to checkpoint inhibitors. Retrospective study.

Our hypothesis is that some constitutional variations in genes involved in immune responses or oncogenesis may influence the response to immunotherapy. Accumulating data are available for the role of polymorphisms of such genes in the response to the “first generation” of immunotherapies such as BCG therapy (Chiong, 2011; Decobert, 2006) or interleukin (Eto, 2013; Erbe, 2017). Much less is known about the influence of those polymorphisms on the response to CPI and especially PD1 inhibitors. Very recently, a Japanese team reported the association of some polymorphisms of PD1 gene and the response to nivolumab in 50 non squamous cell lung carcinoma patients (Nomizo, 2017). To our knowledge, no data have been yet reported on Caucasian HNSCC patients.

Data controller

Dr Esma SAADA-BOUZID

Categories of data used
Données de santé
Origine de données utilisées
Soins
Centre Antoine Lacassagne (Nice)
2017
Population subject to research or data processing

HNSCC cancer

Legal basis

intérêt public

Internal and external data recipients

Centre Antoine Lacassagne

Research start date
24/05/2017
Data retention period

30 ans

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