Mes données de santé
The information site for patients treated within the Unicancer network or included in Unicancer network clinical trials. 

About us

Objectives

EGFR T790M mutation represents around 50% acquired resistance to first generation EGFR TKIs of patients with NSCLC. Its earlier detection is consequently becoming crucial. We here propose an improvement of the PNA-mediated PCR followed by pyrosequencing to develop a highly sensitive method that could in the future be used to confirm conflicting results obtained with the method of reference, next generation sequencing. Moreover, an evaluation of the putative prognostic effect of the p.Gln787Gln polymorphism on EGFR-TKIs response will be performed.

Data controller

Institut de Cancérologie de l'Ouest

Categories of data used
Données d’identification (sans donnée nominative) / Données de santé
Origine de données utilisées
Soins
Institut de Cancérologie de l'Ouest (Nantes et Angers)
2015
Population subject to research or data processing

Patients with NSCLC who relapsed after tyrosine kinase inhibitors targeting EGFR treatments

Legal basis

Intérêt public

Internal and external data recipients

Département de Biopathologie des tumeurs de l'ICO.

Research start date
07/04/2020
Data retention period

Conservation pendant 2 ans après la valorisation (publication/article, thèse, présentation orale, poster, autre) des résultats de la recherche. Puis archivage avec un accès restreint aux personnes intervenant dans la recherche, pendant une durée limitée de 3 ans (5ans au total post publication)

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